Publication Search

Unique local identifier Title Sort descending Abstract

Zhao R, Wang Z, Liu C, Zhang L, Zhang M, Du H, Yang G, Sun H, Liu W, Yan S, Wang M. (20S)-protopanaxatriol attenuates Ang II-induced renal injury via PTPN1-mediated AMPK/mTOR signaling pathway.. Journal of ginseng research. 2025 Nov; 49(6):652…

(20S)-protopanaxatriol attenuates Ang II-induced renal injury via PTPN1-mediated AMPK/mTOR signaling pathway.

BACKGROUND
(20S)-Protopanaxatriol (PPT), a bioactive triterpenoid from Panax ginseng, has been used in Traditional Chinese Medicine (TCM) to tonify kidney yang and regulate blood pressure. The research aimed to elucidate PPT's protective…

Huang YW, Luo F, Zhang M, Wang L, Meng W, Hu D, Yang J, Sheng J, Wang X. 20( S )-Protopanaxatriol Improves Atherosclerosis by Inhibiting Low-Density Lipoprotein Receptor Degradation in ApoE KO Mice.. Journal of cardiovascular pharmacology. 2024…

20( S )-Protopanaxatriol Improves Atherosclerosis by Inhibiting Low-Density Lipoprotein Receptor Degradation in ApoE KO Mice.

Atherosclerosis (AS) is a chronic progressive disease caused by various factors and causes various cerebrovascular and cardiovascular diseases (CVDs). Reducing the plasma levels of low-density lipoprotein cholesterol is the primary goal in…

Zhang JJ, Hu RY, Chen KC, Liu YB, Hou YY, Zhang YZ, Feng ZM, Chen RX, Zheng YN, Liu S, Li W. 20(S)-protopanaxatriol inhibited D-galactose-induced brain aging in mice via promoting mitochondrial autophagy flow.. Phytotherapy research : PTR. 2023…

20(S)-protopanaxatriol inhibited D-galactose-induced brain aging in mice via promoting mitochondrial autophagy flow.

Previous reports have confirmed that saponins (ginsenosides) derived from Panax ginseng. C. A. Meyer exerted obvious memory-enhancing and antiaging effects, and the simpler the structure of ginsenosides, the better the biological activity. In…

Oh GS, Yoon J, Lee GG, Oh WK, Kim SW. 20(S)-protopanaxatriol inhibits liver X receptor α-mediated expression of lipogenic genes in hepatocytes.. Journal of pharmacological sciences. 2015 Jun; 128(2):71-7.

20(S)-protopanaxatriol inhibits liver X receptor α-mediated expression of lipogenic genes in hepatocytes.

20(S)-protopanaxatriol (PPT) is an aglycone of ginsenosides isolated from Panax ginseng and has several interesting activities, including anti-inflammatory and anti-oxidative stress effects. Herein, PPT was identified as an inhibitor against the…

Kim DY, Ro JY, Lee CH. 20(S)-Protopanaxatriol inhibits release of inflammatory mediators inĀ immunoglobulin E-mediated mast cell activation.. Journal of ginseng research. 2015 Jul; 39(3):189-98.

20(S)-Protopanaxatriol inhibits release of inflammatory mediators in immunoglobulin E-mediated mast cell activation.

BACKGROUND
Antiallergic effect of 20(S)-protopanaxatriol (PPT), an intestinal metabolite of ginseng saponins, was investigated in guinea pig lung mast cells and mouse bone marrow-derived mast cells activated by a specific antigen/antibody…

Oh GS, Pae HO, Choi BM, Seo EA, Kim DH, Shin MK, Kim JD, Kim JB, Chung HT. 20(S)-Protopanaxatriol, one of ginsenoside metabolites, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expressions through inactivation of nuclear factor…

20(S)-Protopanaxatriol, one of ginsenoside metabolites, inhibits inducible nitric oxide synthase and cyclooxygenase-2 expressions through inactivation of nuclear factor-kappaB in RAW 264.7 macrophages stimulated with lipopolysaccharide.

Ginsenosides from Panax ginseng are metabolized by human intestinal bacteria after oral administration of ginseng extract. 20(S)-Protopanaxatriol (PPT) is one of the major metabolites of ginsenosides. Inducible nitric oxide synthase (iNOS) and…

Guo WQ, Chen YG, Shi RZ, He K, Wang JF, Shao JH, Wan JB, Gao JL. 20(S)-Protopanaxdiol Suppresses the Abnormal Granule-Monocyte Differentiation of Hematopoietic Stem Cells in 4T1 Breast Cancer-Bearing Mouse.. Evidence-based complementary and…

20(S)-Protopanaxdiol Suppresses the Abnormal Granule-Monocyte Differentiation of Hematopoietic Stem Cells in 4T1 Breast Cancer-Bearing Mouse.

Panax notoginseng (PN) has been used as a qi- and blood-activating (Huoxue) drug for thousands of years in China. It has also been widely used as an anticancer drug at present. As a Huoxue drug, the effect of PN on hematopoietic differentiation…

Li J, Lu J, Ye Z, Han X, Zheng X, Hou H, Chen W, Li X, Zhao L. 20(S)-Rg3 blocked epithelial-mesenchymal transition through DNMT3A/miR-145/FSCN1 in ovarian cancer.. Oncotarget. 2017 Aug 08; 8(32):53375-53386.

20(S)-Rg3 blocked epithelial-mesenchymal transition through DNMT3A/miR-145/FSCN1 in ovarian cancer.

Epithelial-mesenchymal transition (EMT) is one of the key mechanisms mediating cancer progression. MicroRNAs (miRs) are essential regulators of gene expression by suppressing translation or causing degradation of target mRNA. Growing evidence…

Li TY, Ye C, Zhang YJ, Zhang JX, Yang M, He XH, Mei XY, Liu YX, Zhu YY, Huang HC, Zhu SS. 2,3-Butanediol from the leachates of pine needles induces the resistance of Panax notoginseng to the leaf pathogen Alternaria panax.. Plant diversity. 2023…

2,3-Butanediol from the leachates of pine needles induces the resistance of Panax notoginseng to the leaf pathogen Alternaria panax.

Compared with the use of monocultures in the field, cultivation of medicinal herbs in forests is an effective strategy to alleviate disease. Chemical interactions between herbs and trees play an important role in disease suppression in forests.…

Liu Y, Sun M, Wang H, Liu J, Tan G, Yan J, Wang Y, Yan Z, Liu H, Tao J, Zhu W, Shu S, Xiong A. 24-Epibrassinolide and 2,6-Dichlorobenzonitrile Promoted Celery Petioles and Hypocotyl Elongation by Altering Cellulose Accumulation and Cell Length.…

24-Epibrassinolide and 2,6-Dichlorobenzonitrile Promoted Celery Petioles and Hypocotyl Elongation by Altering Cellulose Accumulation and Cell Length BRs (brassinosteroids), an endogenous hormone in plants, regulate cellulose accumulation, cell elongation and plant growth. Propiconazole (PCZ) is an effective inhibitor of BR biosynthesis. DCB (2,6-Dichlorobenzonitrile) can inhibit the synthesis of…

Fontaine J, Grandmougin-Ferjani A, Glorian V, Durand R. 24-methyl/methylene sterols increase in monoxenic roots after colonization by arbuscular mycorrhizal fungi. New phytologist. 2004; 163(1):159-167.

24-methyl/methylene sterols increase in monoxenic roots after colonization by arbuscular mycorrhizal fungi

•  Characteristic sterols of transformed carrot (Daucus carota) and chicory (Cichorium intybus) roots colonized by different strains of arbuscular mycorrhizal (AM) fungi were identified. •  Sterols were extracted, analysed and identified by gas…

Wang Z, Su G, Zhang Z, Dong H, Wang Y, Zhao H, Zhao Y, Sun Q. 25-Hydroxyl-protopanaxatriol protects against H2O2-induced H9c2 cardiomyocytes injury via PI3K/Akt pathway and apoptotic protein down-regulation.. Biomedicine & pharmacotherapy =…

25-Hydroxyl-protopanaxatriol protects against H2O2-induced H9c2 cardiomyocytes injury via PI3K/Akt pathway and apoptotic protein down-regulation.

Oxidative stress injury and apoptosis are the main mechanisms of myocardial ischemia-reperfusion injury (MI/RI). Compounds with anti-oxidant properties can treat MI/RI. Therefore, identification of natural antioxidants such as herbs or botanical…

Wu YL, Wan Y, Jin XJ, OuYang BQ, Bai T, Zhao YQ, Nan JX. 25-OCH3-PPD induces the apoptosis of activated t-HSC/Cl-6 cells via c-FLIP-mediated NF-ĪŗB activation.. Chemico-biological interactions. 2011 Nov 15; 194(2-3):106-12.

25-OCH3-PPD induces the apoptosis of activated t-HSC/Cl-6 cells via c-FLIP-mediated NF-ĪŗB activation.

25-OCH(3)-PPD is a dammarane-type triterpene sapogenin isolated from the roots, leaves and seeds of Panax notoginseng, which has shown anti-tumor effects in several human cancer lines. In this study, we evaluated the effects of 25-OCH(3)-PPD on…

Schmidt J, Voigt B, Adam G. 2-Deoxybrassinolide--a naturally occuring brassinosteroid from Apium graveolens. Phytochemistry. 1995 Nov; 40(4):1041-1043.

2-Deoxybrassinolide--a naturally occuring brassinosteroid from Apium graveolens A new brassinosteroid was detected in seeds of Apium graveolens and it was shown to be 2-deoxybrassinolide by gas chromatography-mass spectral analysis and comparison with suitable reference compounds.

Gao H, Liang D, Li C, Xu G, Jiang M, Li H, Yin J, Song Y. 2-Deoxy-Rh2: A novel ginsenoside derivative, as dual-targeting anti-cancer agent via regulating apoptosis and glycolysis.. Biomedicine & pharmacotherapy = Biomedecine &…

2-Deoxy-Rh2: A novel ginsenoside derivative, as dual-targeting anti-cancer agent via regulating apoptosis and glycolysis.

20(S)-Rh2 is a ginsenoside isolated from Panax ginseng, which exhibits anti-cancer activities on various human cancer cells. A novel 20(S)-Rh2 derivative, 2-Deoxy-Rh2 was synthesized and hybridized with protopanaxadiol and 2-deoxy-glucose in an…

Soria AC, Olano A, Frías J, Peñas E, Villamiel M. 2-Furoylmethyl amino acids, hydroxymethylfurfural, carbohydrates and β-carotene as quality markers of dehydrated carrots. Journal of the science of food and agriculture. 2009; 89(2):267-273.

2-Furoylmethyl amino acids, hydroxymethylfurfural, carbohydrates and β-carotene as quality markers of dehydrated carrots BACKGROUND: Processing of vegetables in the food industry usually includes dehydration as a preservation process. Industrial convective air drying of carrot can involve steam blanching of the raw product after peeling and cutting, and different…

Cronin D, Stanton P. 2-methoxy-3-sec-butylpyrazine--an important contributor to carrot aroma. Journal of the science of food and agriculture. 1976 Feb; 145-151.

2-methoxy-3-sec-butylpyrazine--an important contributor to carrot aroma

De Wang X, Li T, Li Y, Yuan WH, Zhao YQ. 2-Pyrazine-PPD, a novel dammarane derivative, showed anticancer activity by reactive oxygen species-mediate apoptosis and endoplasmic reticulum stress in gastric cancer cells.. European journal of…

2-Pyrazine-PPD, a novel dammarane derivative, showed anticancer activity by reactive oxygen species-mediate apoptosis and endoplasmic reticulum stress in gastric cancer cells.

20 (R)-Dammarane-3β, 12β, 20, 25-tetrol (25-OH-PPD), a ginsenoside, was derived from Panax ginseng (C. A. Meyer) and inhibited growth of several cancer cell lines. To improve the anti-cancer activity, we introduced the pyrazine ring to 25-OH-PPD…

Fox G, Ratcliffe R. 31P NMR observations on the effect of the external pH on the intracellular pH values in plant cell suspension cultures. Plant physiology. 1990 June; 93(2):512-521.

31P NMR observations on the effect of the external pH on the intracellular pH values in plant cell suspension cultures 31P nuclear magnetic resonance (NMR) spectroscopy was used to monitor the response of oil palm (Elaeis guineensis) and carrot (Daucus carota) cell suspensions to changes in the external pH. An airlift system was used to oxygenate the cells during…

Randerath K, Haglund RE, Phillips DH, Reddy MV. 32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. I. Adult female CD-1 mice.. Carcinogenesis.…

32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. I. Adult female CD-1 mice.

The binding of a series of alkenylbenzenes to liver DNA of adult female CD-1 mice, isolated 24 h after i.p. administration of non-radioactive test compound (2 or 10 mg/mouse), was investigated by a modified 32P-post-labelling assay. The known…

Phillips DH, Reddy MV, Randerath K. 32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. II. Newborn male B6C3F1 mice.. Carcinogenesis. 1984 Dec;…

32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. II. Newborn male B6C3F1 mice.

When a series of nine alkenylbenzenes were administered to preweanling male mice, safrole, estragole and methyleugenol induced a significant incidence of hepatic carcinomas, while eugenol, anethole, elemicin, myristicin, dill apiol and parsley…

Chauhan RS, Nautiyal M, Bahuguna Y, Figueredo G, Chalard P. 3, 5-Nonadiyne Rich Accession of Selinum tenuifolium Wall. from Dayara, Uttarakhand, Himalaya. Journal of essential oil-bearing plants. 2017; 20(3):878-882.

3, 5-Nonadiyne Rich Accession of Selinum tenuifolium Wall. from Dayara, Uttarakhand, Himalaya Selinum tenuifolium (Apiaceae) is a perennial aromatic herb, growing in humus rich mountain slopes. Underground parts were extracted for the essential oil by using Clevenger-type apparatus and analyzed. Total twenty two constituents composed of 97…

Farghadani R, Haerian BS, Ebrahim NA, Muniandy S. 35Year Research History of Cytotoxicity and Cancer: a Quantitative and Qualitative Analysis.. Asian Pacific journal of cancer prevention : APJCP. 2016; 17(7):3139-45.

35Year Research History of Cytotoxicity and Cancer: a Quantitative and Qualitative Analysis.

Cancer is the leading cause of morbidity and mortality worldwide, characterized by irregular cell growth. Cytotoxicity or killing tumor cells that divide rapidly is the basic function of chemotherapeutic drugs. However, these agents can damage…

Suzich JA, Dean JF, Herrmann KM. 3-Deoxy-d-arabino-Heptulosonate 7-Phosphate Synthase from Carrot Root (Daucus carota) Is a Hysteretic Enzyme.. Plant physiology. 1985 Nov; 79(3):765-70.

3-Deoxy-d-arabino-Heptulosonate 7-Phosphate Synthase from Carrot Root (Daucus carota) Is a Hysteretic Enzyme.

Roots of carrots (Daucus carota) contain three activities of 3-deoxy-d-arabino-heptulosonate 7-phosphate (DAHP) synthase, the enzyme that catalyzes the first step of the shikimate pathway. The three activities, enzymes I, II, and III, are…

Pinto JE, Suzich JA, Herrmann KM. 3-Deoxy-d-arabino-Heptulosonate 7-Phosphate Synthase from Potato Tuber (Solanum tuberosum L.).. Plant physiology. 1986 Dec; 82(4):1040-4.

3-Deoxy-d-arabino-Heptulosonate 7-Phosphate Synthase from Potato Tuber (Solanum tuberosum L.).

3-Deoxy-d-arabino-heptulosonate 7-phosphate synthase, the first enzyme of the shikimate pathway, was purified to electrophoretic homogeneity from tubers of Solanum tuberosum L. cv Superior. The enzyme is a dimer with a native molecular weight of…